Skip to main content

Tumor Suppressor gene

There is a group of gene which reduce the probabilities of occurring cancerous cell or inhibit the abnormal proliferation by different metabolic activities. And a cell with the mutated Tumor suppressor gene or functionally reduced TSG can progress it to cancer.
Example:-
1. P53 gene:- The protein produced by this gene is of 53 kd, hence the name. It prevent a cell from completing a cell cyclem, 1) if its DNA is damage and 2) the cell is not prepared or injured for normal proliferation. So in these cases it halts the cell cycle until the damaged is reapired and if the damage is too critical then it triggers the cell to commit suicide by programmed cell death of Apopstosis. 70% of colon cancer, 50% of breast cancer and 50% of lung cancer is for mutation of this gene.

2. Rb gene:- it the condition are not adequate to perform the cell divison this gene stops the cell cycle in S phage by blocking the transcription factor c-myc and c-fos, which are necessary factors for the mitosis. And when the stituations become adequate it gets phosphorylated and releases a E2F factor which activate c-myc and c-fos and cell cycle continued.

Fuctions:-
1. repress the genes that are essential for continuing the cell cycle.
2. trigerring the apopstosis in case of critical damge.
3. couples the cell cycle to DNA damage so that it cannot continue until the damage is repaired.



Comments

Popular posts from this blog

National Seminar on Biological Sciences, Bahona College, Jorhat, Assam....

Bahona College, Jorhat is organizing a UGC sponsored national seminar on “Research in Biological Sciences for sustainable development by the application of Mathematics and allied branches”  by  the Departments of Botany, Mathematics and Computer Science in collaboration with Assam Science Society, Bahona Branch on 10th and 11th May, 2013Thrust areas: ·Recent research in Biological Sciences for sustainability. · Biophysics and Biochemistry research for sustainability. ·Issues related to global environmental crisis, biodiversity loss and conservation. ·Management of Bioresources. ·Phytochemical and Zoochemical investigations to validate the traditional knowledge. ·Critical needs in agricultural and biofuel production. ·Management of Alien species. ·Biotechnology research for sustainability. ·Mathematics and 21st Century Biology. ·Mathematical modeling ·Fluid mathematics ·Fuzzy mathematics ·Statistics in Biological research. ·Systems Biology ·Computational Biology/Bio Computing.

Influenza A detection by MDCK cell line

The influenza A (IA) virus is the principal cause of the outbreaks of flu. A large number of laboratories participate in the worldwide surveillance of influenza virus activity and contribute to the early recognition of newly emerging epidemic strains. Differentiation between influenza A and B viruses and determination of the subtypes of influenza A virus isolates are the first steps in the characterization of influenza viruses. This analysis is traditionally done by hemagglutination inhibition (HI) tests with specific antisera raised in ferrets, chickens, or sheep.
The diagnosis of Influenza A is largely clinical. Nevertheless, it is necessary to carry out some form of rapid antigenic diagnosis and the culture of respiratory samples to confirm the etiology of the respiratory disease and to determine the antigenic characteristics of the epidemic strains. Although the “gold standard” isolation technique is inoculation in embryonated hens’ eggs, the technical difficulties involved and …

SOME INSTITUTE FOR SUMMER TRAINING/FINAL YEAR DISSERTATION/INTERNSHIP..

Center For Cellular and Molecular Biology (CCMB)
<http://www.ccmb.res.in/>.

Central Drug Research Institute (CDRI) <http://www.cdriindia.org/>

Central Food Technological Research Institute (CFTRI)
<http://www.cftri.com/>

Central Institute of Medicinal and Aromatic Plants (CIMAP),
<http://www.cimap.res.in/>

Central Leather Research Institute (CLRI) Chennai <http://www.clri.org/>

Institute of Genomics and Integrative Biology (IGIB)<http://www.igib.res.in/>

Institute of Himalayan Bioresource Technology (IHBT),<http://www.ihbt.res.in/>

Indian Institute of Chemical Biology (IICB)<http://www.iicb.res.in/>

Indian Institute of Chemical Technology (IICT),
<http://www.iictindia.org/>

Institute of Microbial Technology (IMTECH)<http://imtech.res.in/>

Indian Toxicology Research Center (ITRC) <http://www.itrcindia.org/>

National Chemical Laboratory (NCL) Pune <http://www.ncl-india.org/>

National Environmental Engineering Research Institute (N…