Parasporin....An Anti-Cancer Protein

Parasporin, a novel protein with a unique cytocidal activity, was first discovered from Non-Insecticidal Bacillus thuringiensis by Mizuki et al.. The term parasporin is defined as "Bacillus thuringiensis and related bacterial parasporal proteins that are non-hemolytic but capable of preferentially killing cancer cells".

The whole idea came from the view that, it has been well established that Non-insecticidal B. thuringiensis strains are more widely distributed than insecticidal ones, and which raises a question whether such non-insecticidal inclusions have any biological activity which is as yet undiscovered. And astoundingly on the road to find the answer a strong cytocidal protein has been discovered which have activities against human cancer cells. The proteins were heterogeneous in cytotoxicity spectra

Source: a. http://parasporin.fitc.pref.fukuoka.jp/index.html

b. Parasporin, a Human Leukemic Cell-Recognizing Parasporal Protein of Bacillus thuringiensis,

EIICHI MIZUKI et. al., 2000, CLINICAL AND DIAGNOSTIC LABORATORY

IMMUNOLOGY

Influenza A detection by MDCK cell line

The influenza A (IA) virus is the principal cause of the outbreaks of flu. A large number of laboratories participate in the worldwide surveillance of influenza virus activity and contribute to the early recognition of newly emerging epidemic strains. Differentiation between influenza A and B viruses and determination of the subtypes of influenza A virus isolates are the first steps in the characterization of influenza viruses. This analysis is traditionally done by hemagglutination inhibition (HI) tests with specific antisera raised in ferrets, chickens, or sheep. The diagnosis of Influenza A is largely clinical. Nevertheless, it is necessary to carry out some form of rapid antigenic diagnosis and the culture of respiratory samples to confirm the etiology of the respiratory disease and to determine the antigenic characteristics of the epidemic strains. Although the “gold standard” isolation technique is inoculation in embryonated hens’ eggs, the technical difficulties involved and t...

WORKSHOP ON: Prospecting Traditional Herbal Therapy to Modern Drug Discovery

The Institutional Biotech Hub, Department of Biotechnology, Gauhati University is organizing a 7 days’ workshop cum training program on “Prospecting Traditional Herbal Therapy to Modern Drug Discovery” from 22nd May to 28th May 2017. The last date for receipt of application form is 15th May 2017. Interested participants may visit the following link for details and to download the application form. http://www.gauhati.ac.in/notification/1492772527biotech%20hub%20workshop2017.pdf

SOME INSTITUTE FOR SUMMER TRAINING/FINAL YEAR DISSERTATION/INTERNSHIP..

Center For Cellular and Molecular Biology (CCMB) <http://www.ccmb.res.in/>. Central Drug Research Institute (CDRI) <http://www.cdriindia.org/> Central Food Technological Research Institute (CFTRI) <http://www.cftri.com/> Central Institute of Medicinal and Aromatic Plants (CIMAP), <http://www.cimap.res.in/> Central Leather Research Institute (CLRI) Chennai <http://www.clri.org/> Institute of Genomics and Integrative Biology (IGIB)<http://www.igib.res.in/> Institute of Himalayan Bioresource Technology (IHBT),<http://www.ihbt.res.in/> Indian Institute of Chemical Biology (IICB)<http://www.iicb.res.in/> Indian Institute of Chemical Technology (IICT), <http://www.iictindia.org/> Institute of Microbial Technology (IMTECH)<http://imtech.res.in/> Indian Toxicology Research Center (ITRC) <http://www.itrcindia.org/> National Chemical Laboratory (NCL) Pune <http://www.ncl-india.org/> National Environmental Engineering Resear...

BIOTECHNOLOGY

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